Recombinant Rat High affinity immunoglobulin epsilon receptor subunit alpha (Fcer1a)

in vitro E.coli expression system

中文名稱：

大鼠Fcer1a重組蛋白
貨號：

CSB-CF008532RA
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Fcer1a
Uniprot No.：

P12371
別名：

Fcer1a; Fce1a; High affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

24-245
氨基酸序列

ATQKSVVSLDPPWIRILTGDKVTLICNGNNSSQMNSTKWIHNDSISNVKSSHWVIVSATIQDSGKYICQKQGFYKSKPVYLNVMQEWLLLQSSADVVLDNGSFDIRCRSWKKWKVHKVIYYKDDIAFKYSYDSNNISIRKATFNDSGSYHCTGYLNKVECKSDKFSIAVVKDYTIEYRWLQLIFPSLAVILFAVDTGLWFSTHKQFESILKIQKTGKGKKKG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
基因功能參考文獻：
1. Differential Ca(2+) mobilization and mast cell degranulation by FcepsilonRI- and GPCR-mediated signaling has been reported. PMID: 29029788
2. This study reveals a complex regulation for PLSCR1 tyrosine phosphorylation in FcepsilonRI-activated mast cells, and that PLSCR1 sits at a crossroads between Lyn and Fyn pathways. PMID: 25289695
3. Data suggest M2PK (M2-type pyruvate kinase) is modulated in mast cell degranulation via IgE/FCERI signaling; immediate inhibition of M2PK involves tyrosine phosphorylation; subsequently fructose-1,6-biphosphate accumulates and activates M2PK. PMID: 24497038
4. PTP-PEST expression was significantly induced upon FcepsilonRI-crosslinking, and aggregation of FcepsilonRI induced the phosphorylation of PTP-PEST at Ser39, thus resulting in the suppression of PTP activity. PMID: 24791697
5. NK-1 receptor is required for the activation of RBL-2H3 cells following FcepsilonRIota engagement and involved in the regulation of mitogen-activated protein kinase signaling pathways PMID: 22820943
6. results reveal intricate functional interactions among different cis-acting elements of IgE receptor in the transcriptional regulation of cox-2. Fyn-->PI 3-kinase-->Akt pathway directly stimulate PMID: 22613973
7. Data show that among expressed chemokines and cytokines, only CCL2, CCL7 and interleukin (IL)-6 were expressed at higher levels following FcepsilonRI-CCR1 costimulation. PMID: 22417871
8. These data suggest that CD84 may play a role in modulating Fc epsilon RI-mediated signaling in mast cells. PMID: 18243321
9. Data show that EGFR, via interaction with FcvarepsilonRI and integrin alpha(5), is necessary for allergic inflammation associated with cellular interaction. PMID: 21349584
10. In an immunological model, although serial engagement is not required for rat mast cell signaling, it can influence recruitment of Syk kinase to the receptor and subsequent Syk phosphorylation. PMID: 20733205
11. The spatiotemporal dynamics of the redistribution of immunoglobulin E-loaded receptors (IgE-FcepsilonRI) on rat basophilic leukemia-2H3 mast cells, was quatified. PMID: 20643056
12. Mast cells produce intercellular connections and that mediators are directionally released upon co-stimulation of FcepsilonRI and CCR1. PMID: 20173038
13. pineal Fcer1a mRNA levels are controlled by a well described neural pathway PMID: 17728245
14. Glycosylated FcepsilonRI alpha chain is required for activation of mast cells for IL-4 production by M. pneumoniae. PMID: 18042342
15. Ca(2+) signaling pathway via a sphingosine kinase (SK) is dependent on clathrin. PMID: 18675457
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亞細胞定位：

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
組織特異性：

Expressed in leukocytes and pinealocytes at night (at protein level).
數據庫鏈接：

KEGG: rno:25047

STRING: 10116.ENSRNOP00000054898

UniGene: Rn.9677