Recombinant Sheep F-box/LRR-repeat protein 21 (Fbxl21)

中文名稱：

綿羊Fbxl21重組蛋白
貨號：

CSB-YP008473SH
規格：
來源：

Yeast
其他：

中文名稱：

綿羊Fbxl21重組蛋白
貨號：

CSB-EP008473SH
規格：
來源：

E.coli
其他：

中文名稱：

綿羊Fbxl21重組蛋白
貨號：

CSB-EP008473SH-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

綿羊Fbxl21重組蛋白
貨號：

CSB-BP008473SH
規格：
來源：

Baculovirus
其他：

中文名稱：

綿羊Fbxl21重組蛋白
貨號：

CSB-MP008473SH
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Fbxl21
Uniprot No.：

B3FL73
別名：

Fbxl21F-box/LRR-repeat protein 21; F-box and leucine-rich repeat protein 21
種屬：

Ovis aries (Sheep)
蛋白長度：

Full length protein
表達區域：

1-434
氨基酸序列

MKRNRLSFMN KVLLSSPAVK QPRLGCCSPL SQAHMRAARL DWGSLPHRVV LCVFQYLPLI DRARASSVCR RWNEVFHIPD LWRKFEFELN QSATSYFNST HPDLIQQIIK KHAAHLQYVS FKVDSSTESA EAACGILSQL VNCSTQTLGL ISTAKPSFMT MSKSHFVSAL TVLFVNSKSL SSIKIEDTPV DDPSLSILVA NNSDTLRRLK MSSCPHVSSD GILCVADHCQ GLRELALNYY MLSDELLLAL SNETHVNLEH LRIDVVSENP GQIEFHSIKR QSWDALIKHS PGVNVVMYFF LYEEEMETFF KEETPVTHLY FGRSVSKGIL GRLSLNCPRL VELVVCANGI QVIDNELICI AEHCKNLTAL GLSECEVSCT AFIEFVRLCG RKLTHLSIME DVLIPDDVCS LDEIHTEVSK YLGRIWFPDV MPVW
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.
基因功能參考文獻：
1. Fbxl21 is a novel circadian clock-controlled gene that plays a specific role within the mammalian circadian pacemaker. PMID: 18953409
亞細胞定位：

Cytoplasm, cytosol. Nucleus.
組織特異性：

Expressed in the adenohypophysis, hypothalamus (especially in the suprachiasmatic nucleus or nuclei, SCN) and pineal, all neuroendocrine structures associated with timing and homeostasis.
數據庫鏈接：

KEGG: oas:100169936

UniGene: Oar.17404