Recombinant Rat Ras-related protein Rab-18 (Rab18)

中文名稱：

大鼠Rab18重組蛋白
貨號：

CSB-YP707836RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Rab18重組蛋白
貨號：

CSB-EP707836RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Rab18重組蛋白
貨號：

CSB-EP707836RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Rab18重組蛋白
貨號：

CSB-BP707836RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Rab18重組蛋白
貨號：

CSB-MP707836RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Rab18
Uniprot No.：

Q5EB77
別名：

Rab18; Ras-related protein Rab-18
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-203
氨基酸序列

MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD NWLNELETYC TRNDIVNMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA SAKTCDGVQC AFEELVEKII QTPGLWESEN QNKGVKLSPR EESHGGGACG GYC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration.
基因功能參考文獻：
1. Data suggest that overexpression of Rab18 in its GDP-bound state favors peroxisome proliferation in hepatocytes; Rab18 (as well as Rab6, Rab10, and Rab14) localizes to the peroxisomal compartment. PMID: 23333653
2. Overexpression of brain RAB18 in alloxan diabetes leads to uneven distribution and function of intracellular-vesicular transport causing accumulation of protein inside the cell, this results in neurological disorder. PMID: 21112318
3. in neuroendocrine cells, Rab18 acts as a negative regulator of secretory activity, likely by impairing secretory granule transport PMID: 17488286
亞細胞定位：

Apical cell membrane. Lipid droplet.
蛋白家族：

Small GTPase superfamily, Rab family
數據庫鏈接：

KEGG: rno:307039

STRING: 10116.ENSRNOP00000025828

UniGene: Rn.221766