Recombinant Rat Pendrin (Slc26a4), partial

中文名稱：

大鼠Slc26a4重組蛋白
貨號：

CSB-YP865637RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Slc26a4重組蛋白
貨號：

CSB-EP865637RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Slc26a4重組蛋白
貨號：

CSB-EP865637RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Slc26a4重組蛋白
貨號：

CSB-BP865637RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Slc26a4重組蛋白
貨號：

CSB-MP865637RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc26a4
Uniprot No.：

Q9R154
別名：

Slc26a4; Pds; Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Sodium-independent transporter of chloride and iodide.
基因功能參考文獻：
1. These studies implicate the involvement of pendrin-facilitated chloride-bicarbonate exchange in the regulation of airway surface liquid volume and suggest the utility of pendrin inhibitors in inflammatory lung diseases. PMID: 26932931
2. these data suggest that pendrin may have an important role in mediating iodide efflux in thyrocytes, especially under conditions of iodide excess. PMID: 26791486
3. Pendrin is expressed in the adrenal medulla, where it blunts stress-induced catecholamine release. PMID: 26173457
4. Expression of slc26a4, slc26a6 and slc26a9 is increased in proximal tubule epithelial cells from spontaneously hypertensive rats compared with WKY control rats. PMID: 23933130
5. Excessive mucus production, as implicated by significant overexpression of the pendrin coding gene, SLC26A4, was identified as a potential novel mechanism for silica-induced pulmonary toxicity. PMID: 22431001
6. These data show that intracellular iodide rapidly upregulates SLC26A4 mRNA expression. PMID: 22178794
7. its presence in both the apical plasma membrane and the apical intracellular vesicles of type B and non-A-non-B intercalated cells suggests that HCO secretion may be regulated by trafficking between the two membrane compartments PMID: 12217866
8. metabolic acidosis decreases the activity of the apical Cl(-)/HCO(3)(-) exchanger in beta-ICs of the rat CCD by reducing the expression of pendrin. PMID: 12388388
9. Metabolic acidosis and alkalosis with maintained water and sodium intake affected pendrin expression in kidney cortex collecting duct cells; regulation of pendrin expression may be clinically important in the correction of acid-base disturbances PMID: 12556366
10. Pds(pendrin protein) expression is specifically regulated in response to changes in chloride balance in the rat kidney PMID: 15292050
11. pendrin expression is regulated in acidotic rats with no changes in aldosterone & no external Cl load.Pendrin reduction may help redirect tubules to Cl excretion & HCO3 reabsorption, leading to increased plasma HCO3 & decreased Cl of respiratory acidosis. PMID: 17182533
12. pendrin expression and localisation are regulated by insulin and influenced by a PKC-epsilon-dependent intracellular pathway. PMID: 18459119
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亞細胞定位：

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
蛋白家族：

SLC26A/SulP transporter (TC 2.A.53) family
數據庫鏈接：

KEGG: rno:29440

STRING: 10116.ENSRNOP00000010350

UniGene: Rn.11792