Recombinant Rat Myotrophin (Mtpn)

中文名稱：

大鼠Mtpn重組蛋白
貨號：

CSB-YP015195RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Mtpn重組蛋白
貨號：

CSB-EP015195RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Mtpn重組蛋白
貨號：

CSB-EP015195RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Mtpn重組蛋白
貨號：

CSB-BP015195RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Mtpn重組蛋白
貨號：

CSB-MP015195RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mtpn
Uniprot No.：

P62775
別名：

Mtpn; Gcdp; Myotrophin; Granule cell differentiation protein; Protein V-1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-118
氨基酸序列

CDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD GLTALEATDN QAIKALLQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.
基因功能參考文獻：
1. Data provide evidence that the coherence of p53 with myotrophin plays an active role during the transition of cardiac hypertrophy to heart failure. PMID: 20202977
2. Equilibrium folding and stability of myotrophin: a model ankyrin repeat protein. PMID: 12079376
3. regulates catecholamine biosynthesis in a catecholaminergic phenotype-dependent manner PMID: 12297298
4. role in controlling catecholamine secretion in PC12D cells PMID: 12387873
5. V-1 expression is increased by hypertension in DS rat atrium. PMID: 12419325
6. V-1 plays a role in prenatal muscle differentiation and postnatal muscle regeneration. PMID: 12467730
7. expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein PMID: 12488317
8. stretching of cardiac myocytes by pressure or volume caused significant increase in the transcript levels of myotrophin , which in turn is responsible for the initiation process of myocardial hypertrophy PMID: 15532712
9. Data strongly suggest that myotrophin appears to be a candidate gene for cardiac hypertrophy and heart failure. PMID: 15946807
10. Results suggest that myotrophin V1 is a predominantly cytosolic protein that could regulate the NFkappa-beta mediated transcription process. PMID: 17041682
11. characterisation of the small ankyrin repeat protein myotrophin PMID: 17113103
12. after internalization into myocytes, myotrophin cotranslocates into the nucleus with p65 to stimulate myocyte growth. PMID: 18693253
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亞細胞定位：

Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
蛋白家族：

Myotrophin family
數據庫鏈接：

KEGG: rno:79215

STRING: 10116.ENSRNOP00000015808

UniGene: Rn.3239