Recombinant Protein lap1 (let-413), partial

中文名稱：

秀麗隱桿線蟲let-413重組蛋白
貨號：

CSB-YP530131CXY
規格：
來源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲let-413重組蛋白
貨號：

CSB-EP530131CXY
規格：
來源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲let-413重組蛋白
貨號：

CSB-EP530131CXY-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲let-413重組蛋白
貨號：

CSB-BP530131CXY
規格：
來源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲let-413重組蛋白
貨號：

CSB-MP530131CXY
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

let-413
Uniprot No.：

O61967
別名：

let-413; F26D11.11; Protein lap1; Lethal protein 413
種屬：

Caenorhabditis elegans
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical junctions.
基因功能參考文獻：
1. LET-413 is required for DENN-4-mediated RAB-10 activation, and the LET-413-assisted RAB-5 to RAB-10 cascade contributes to the integrity of C. elegans intestinal epithelia. PMID: 29079669
2. These results represent the first in vivo analysis of requirements for the L27 domain of a Discs-large/SAP97 protein, identify a crucial LET-413/Scribble regulatory motif. PMID: 18411252
3. requirement for LET-413 and DLG-1 in the polarization of the spermathecal cells PMID: 19109941
亞細胞定位：

Basolateral cell membrane; Peripheral membrane protein.
蛋白家族：

LAP (LRR and PDZ) protein family
組織特異性：

Expressed in the terminal web of the intestine. Expressed in seam cells.
數據庫鏈接：

KEGG: cel:CELE_F26D11.11

STRING: 6239.F26D11.11b

UniGene: Cel.6189