Recombinant Mouse Sodium-dependent phosphate transporter 1 (Slc20a1), partial

中文名稱：

小鼠Slc20a1重組蛋白
貨號：

CSB-YP717219MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Slc20a1重組蛋白
貨號：

CSB-EP717219MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Slc20a1重組蛋白
貨號：

CSB-EP717219MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Slc20a1重組蛋白
貨號：

CSB-BP717219MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Slc20a1重組蛋白
貨號：

CSB-MP717219MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc20a1
Uniprot No.：

Q61609
別名：

Slc20a1; Glvr1; Pit1; Sodium-dependent phosphate transporter 1; Gibbon ape leukemia virus receptor 1; GLVR-1; Leukemia virus receptor 1 homolog; Phosphate transporter 1; PiT-1; Solute carrier family 20 member 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification.; (Microbial infection) May function as a retroviral receptor but do not confer infection susceptibility to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B).
基因功能參考文獻：
1. These data support the involvement of phosphate transporter 1, hereafter referred to as Pi T-1, in the initiation of skeletal mineralization and provide compelling evidence that PHOSPHO1 function is involved in MV biogenesis PMID: 26773408
2. propose the novel idea that PiT-1 is central to the regulation of endocytosis and autophagy in the yolk sac visceral endoderm PMID: 25138534
3. Pi uptake-dependent and -independent functions of PiT-1 are important for vascular smooth muscle cell processes mediating vascular calcification. PMID: 25684711
4. Mechanistically, PiT-1 and PiT-2 seem to serve redundant roles in phosphate-induced calcification of vascular smooth muscle cells. PMID: 23968976
5. Data indicate that mice lacking SLC20A1 (PiT1) develop a profound underproduction anemia characterized by mild macrocytosis, dyserythropoiesis, increased apoptosis, and a near complete block in terminal erythroid differentiation. PMID: 23376999
6. Incisor enamel formation is impaired in transgenic rats overexpressing the type III NaPi transporter Slc20a1. PMID: 21643723
7. that cellular ATP synthesis consequent to P(i) uptake via Pit-1 plays an important role in chondrocyte apoptosis and mineralization, and that chondrogenesis is ATP-dependent. PMID: 21075853
8. Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis. PMID: 20817733
9. Data illustrate a specific in vivo role for PiT1 by uncovering it as being a critical gene for normal developmental liver growth. PMID: 20161774
10. investigation of function of piT-1 using transgenic rats: overexpression of piT-1 decreased alkaline phosphatase activity in osteoblasts without influencing bone matrix mineralization or skeletal development PMID: 19795094
11. Inorganic phosphate effects on Glvr-1 and -2 up-regulation require the presence of calcium and involve ERK signalling pathways. PMID: 19232318
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Inorganic phosphate transporter (PiT) (TC 2.A.20) family
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

KEGG: mmu:20515

STRING: 10090.ENSMUSP00000028880

UniGene: Mm.272675