Recombinant Mouse Periostin (Postn), partial
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中文名稱：小鼠Postn重組蛋白
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貨號：CSB-EP720283MO-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：Postn; Osf2; Periostin; PN; Osteoblast-specific factor 2; OSF-2
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種屬：Mus musculus (Mouse)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
相關產品
靶點詳情
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功能：Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX.
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基因功能參考文獻：
- Inhibition of periostin could be important for suppressing capsule formation on silicone implants after in vivo implantation. PMID: 29854742
- Unaffected by Postn, Vav-Itgav(-/-) haematopoietic stem cell proliferate faster in vitro, illustrating the importance of Postn-Itgav interaction. PMID: 27905395
- mesenchymal source, specific to cardiovascular tissues, roles in cardiovascular development and disease [review] PMID: 29101484
- Results indicate that periostin is a key player in the development of bleomycin-induced fibrosis and consequent enhancement of tumor cell colonization in the lung. PMID: 29498146
- Periostin gene deletion impairs periosteal cells functions and fracture consolidation. PMID: 29472541
- these data indicate that CatK not only plays a major role in bone remodeling but also modulates modeling-based cortical bone formation by degrading periostin and thereby moderating Wnt-beta-catenin signaling. PMID: 28322464
- Ablation of periostin suppresses post-infarction myocardial regeneration by inhibiting the PI3K/GSK3beta/cyclin D1 signalling pathway, indicating that periostin is essential for myocardial regeneration. PMID: 28453729
- this study shows that periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis PMID: 27435108
- Genetic or pharmaco-genetic inhibition of periostin in animal models of renal disease was efficient in arresting the progression of the kidney pathology. (Review) PMID: 28884334
- TGFBI and periostin act similarly in the heart in affecting fibrosis and disease responsiveness. PMID: 28750100
- Results suggest that stromal cell periostin (POSTN) supports both normal hematopoietic progenitor cells (HPCs) and leukemia-initiating cells in vitro. PMID: 27596966
- the expressions of the periostin splice variants were increased in ischemic retinas. PMID: 27744020
- POSTN regulates the scar formation after spinal cord injuries. PMID: 28082119
- periostin in the extracellular matrix architecture prevents pulmonary leakage of blood fluid, thus increasing the survival rate in mice with acute lung injury PMID: 27270966
- These results indicated that tensile stress load increased the expression levels of PN in mouse peridontal ligaments and human periodontal ligament cells. PMID: 28260019
- POSTN promotes the pulmonary accumulation of myeloid-derived suppressor cells (MDSCs) during the early stage of breast tumour metastasis. Postn deletion decreases neutrophil and monocytic cell populations in the bone marrow of mice and suppresses the accumulation of MDSCs to premetastatic sites. PMID: 27193093
- Fibrillin-2 and periostin are target genes in Osterix-mediated osteoblast differentiation. PMID: 27751812
- Periostin mediates intestinal inflammation through the activation of NF-kappaB signaling, which suggests that periostin is a potential therapeutic target for inflammatory bowel disease. PMID: 26890265
- Thus, these results demonstrate a subcellular role of periostin in promotion of fibronectin secretion from the ER. PMID: 26820539
- These data demonstrate that the expression of periostin is stimulated by ErbB ligand NRG1 and influences the migration of Schwann cell precursors. PMID: 26187852
- Our data suggest that POSTN is a crucial factor for proper exocrine lineage-specific regeneration after severe acute pancreatitis. PMID: 26632158
- Periostin functions as a regulator of atherosclerotic lesion formation and progression. PMID: 26564821
- HMGB1 expression in the periodontal ligament is differentially regulated during orthodontic tooth movement in wild type versus periostin-deficient mice. PMID: 25948513
- POSTN was expressed in the region surrounding melanoma cell nests in metastatic lesions of both wounded mice and the patient. PMID: 26083413
- POSTN significantly enhances neural stem cell proliferation and differentiation after hypoxia-ischemia. PMID: 25894199
- loss of Postn in an ErbB2/Neu/HER2 overexpression model results in apocrine-like tumors that activate an AR-dependent pathway. PMID: 25592291
- Periostin appears to be a mediator for epidermal hyperplasia that is common to AD and psoriasis. PMID: 25572557
- Deficiency in periostin abrogated the development of liver fibrosis in mice. PMID: 25541330
- key pathologic factors responsible for bone and periodontal ligament damage in periostin-null mice PMID: 25757567
- These results further indicate that periostin is an essential mediator of cortical bone response to mechanical forces (loading and unloading). PMID: 25445447
- This study found that the secreted protein periostin (Postn) is highly induced after partial pancreatectomy in regenerating areas containing mesenchymal stroma and tubular complexes. PMID: 25485969
- Periostin might be associated with pathophysiology in post-ischemic inflammation and neurogenesis. PMID: 24646642
- Overexpression of periostin resulted in reduced expression of peroxisome proliferator-activated receptor alpha (PPARalpha), a master regulator of fatty acid oxidation, and activation of the JNK signaling pathway. PMID: 25003192
- In mice, periostin is required for maximal airways hyperresponsiveness and inflammation after house dust mite sensitization and challenge. PMID: 24996263
- periostin deficiency may not only cause periodontal ligament collagen fibril disorganization, but could also affect the distribution of other major extracellular matrix proteins such as fibronectin and tenascin C. PMID: 24352874
- periostin plays an essential role in the function of collagenolytic enzymes like cathepsin K, MMP1 and MMP2 in the compressed PDL after orthodontic force application. PMID: 24202437
- adversely modifies the progression of renal cystic disease by promoting cyst epithelial cell proliferation, cyst enlargement, and interstitial fibrosis PMID: 24284511
- Periostin-induced epithelial migration and proliferation requires mTOR signaling. PMID: 24349533
- Periostin and a paracrine loop composed of IL-1alpha and IL-6 regulates keratinocyte proliferation and differentiation in the epithelial-mesenchymal interactions, and periostin tunes the magnitude of keratinocyte proliferation and differentiation. PMID: 24352037
- Periostin/beta-INTEGRINs/focal adhesion kinase/PI3K/ERK signals promote hyaluronan synthase-2 activation, matrix remodeling, and valve progenitor cell survival/differentiation. PMID: 24469446
- the level of periostin expression could influence the propensity to fatigue fractures. PMID: 24167618
- Periostin downregulation is an early marker of inhibited neonatal murine lung alveolar septation. PMID: 23723163
- Metabolic activity of CYP1B1 contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of Postn expression. PMID: 23979599
- Clear cell renal cell carcinoma induces fibroblast-mediated accumulation of stromal periostin, enhancing tumor cell attachment and fibroblast proliferation. PMID: 23896380
- periostin exacerbates the pathogenesis of AD through TSLP production from keratinocytes. PMID: 22918211
- Periostin plays an essential role in the pathogenesis of Bleomycin-induced scleroderma in mice. PMID: 22911870
- These results suggest that periostin, which is secreted by the intraocular macrophages, enhances the hyaloidvascular system regression by intensifying the adhesion of macrophages to hyaloid vessels. PMID: 22930727
- Periostin regulates beta catenin signaling and parathyroid hormone anabolic effects in bone. PMID: 22927401
- Periostin overexpression is associated with kidney injury. PMID: 22167593
- periostin sets up a vicious circle that links Th2-type immune responses to keratinocyte activation and plays a critical role in the amplification and chronicity of allergic skin inflammation. PMID: 22684102
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亞細胞定位：Golgi apparatus. Secreted. Secreted, extracellular space, extracellular matrix.
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組織特異性：Preferentially expressed in periosteum and periodontal ligament. Also expressed in the developing and adult heart.
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數據庫鏈接：
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