Recombinant Mouse Microtubule-associated protein 2 (Map2), partial

中文名稱：

小鼠Map2重組蛋白
品名簡稱：

Recombinant Mouse Map2 protein, partial
貨號：

CSB-EP013408MO
說明書：

MSDS Datasheet
規格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Map2
Uniprot No.：

P20357
別名：

Map2; Mtap2; Microtubule-associated protein 2; MAP-2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
來源：

E.coli
分子量：

54.0kDa
表達區域：

213-559aa
氨基酸序列

GMEGEKLPPVPFAQTFGTNLEDRKQSTEPSIVMPSIGLSAEPPAPKEPKDWFIEMPTESKKDEWGLAAPISPGPLTPMREKDVLEDIPRWEGKQFDSPMPSPFHGGSFTLPLDTMKNERVSEGPRPFAPVFFQSDDKVSLQDPSALATSKESSKDEEPLKDKADKVADVSISEVTTLLGNVHSPVVEGYVGENISGEVKVTTDQEKKETSAPSVQEPTLTETEPQTKLDEKSTVSIEEAVAKKEESFKLRDDKTGVIQTSTEQSFSKEDQKGQEHTIDELKQDSFPISLEQAVTDAAMTSKTLGKVTSEPEAVSERREIQGLFEEKTADKNKLEGAGSATIAEVEMP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-SUMO-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
基因功能參考文獻：
1. MAP2c levels in different brain regions of aging mice were positively correlated with neuropsin expression. PMID: 24965600
2. Accumulation of intraneuronal beta-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses. PMID: 23372648
3. results demonstrate the structural and functional determinant underlying the v-KIND-MAP2 interaction that controls dendrite arborization patterns PMID: 21385318
4. Increased MAP2 expression in malignant melanoma cells significantly inhibits tumor cell growth and neoplasm invasiveness, and induces apoptosis and cell cycle arrest. PMID: 20100193
5. Data show that inhibition of ZNF238 (RP58) expression in mouse GNPs decreases the expression of the neuronal differentiation markers MAP2 and NeuN and downregulates the expression of the cell cycle arrest protein p27, a regulator of GNP differentiation. PMID: 20103640
6. Nitric oxide affects the phosphorylation state of microtubule-associated protein 2 in brain. PMID: 11829530
7. PKA binding to MAP2 and MAP2 phosphorylation is essential for the selective development of contextual memory. PMID: 12763072
8. Multiple brain regions exhibit potential for endogenous recovery and/or reorganization of MAP2 after injury of moderate traumatic severity. PMID: 14588114
9. As young adults, S100B transgenic mice exhibit significantly greater MAP-2-immunoreactivity in the hippocampus, however in older adults, less MAP-2 staining is exhibited. PMID: 15306236
10. JNK1 phosphorylation of MAP2 plays an important role in defining dendritic architecture in the brain. PMID: 16000625
11. We also propose MAP2-deficient mice as an ideal system for identifying protein phosphatases essential for dendritic functions. PMID: 16257389
12. MAP2 was increased in old females compared with both young and middle-age females with no significant difference in males, suggesting it may constitute a compensatory response to age-related functional decline in mice. PMID: 16330151
13. TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites PMID: 16901895
14. v-KIND mediates a signaling pathway that links Ras and MAP2 to control dendrite growth PMID: 17984326
15. AKAP150 and Mtap2 put TREK channels at the center of a complex protein network that finely tunes channel trafficking, addressing, and regulation. PMID: 18716213
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亞細胞定位：

Cytoplasm, cytoskeleton. Cell projection, dendrite.
數據庫鏈接：

KEGG: mmu:17756

STRING: 10090.ENSMUSP00000109650

UniGene: Mm.256966