Recombinant Mouse Delphilin (Grid2ip), partial

中文名稱：

小鼠Grid2ip重組蛋白
貨號：

CSB-YP611312MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Grid2ip重組蛋白
貨號：

CSB-EP611312MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Grid2ip重組蛋白
貨號：

CSB-EP611312MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Grid2ip重組蛋白
貨號：

CSB-BP611312MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Grid2ip重組蛋白
貨號：

CSB-MP611312MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Grid2ip
Uniprot No.：

Q0QWG9
別名：

Grid2ipDelphilin; Glutamate receptor; ionotropic; delta 2-interacting protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Postsynaptic scaffolding protein at the Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.
基因功能參考文獻：
1. A direct link exists between GluR2delta receptor and stimulation of the autophagic pathway in dying Purkinje cells of lurcher mice. PMID: 12372286
2. Absence of GRID2 receptors in heteroallelic mutants induces an early and massive Purkinje cell death that is correlated with early signs of autophagy and is independent of depolarization. PMID: 12628171
3. Results show that the Delphilin protein exhibits diversity at its N-terminus by variable usage of the first several exons. PMID: 16168524
4. findings are compatible with the idea that LTD induction at PF-PC synapses is a crucial rate-limiting step in optokinetic resonse gain-increase adaptation, a simple form of motor learning PMID: 18509461
亞細胞定位：

[Isoform 2]: Cell junction, synapse, postsynaptic cell membrane. Cell projection, dendritic spine. Note=Localized to the postsynaptic junction site of the parallel fiber-Purkinje cell synapse. Highly present in the dendritic spines.; [Isoform 3]: Cell junction, synapse. Cell projection, dendritic spine. Cell membrane; Lipid-anchor. Note=Localized at the dendritic spines, but also in dendritic shafts apart fron spines.
組織特異性：

Isoform 1 is expressed in the cerebellum, but not in the cerebral cortex. Isoform 2 is expressed in the cell body of purkinge cells of the cerebellum and weakly expressed in the cerebrum and the brainstem as well as various nuclei of the thalamus. Isoform
數據庫鏈接：

KEGG: mmu:170935

STRING: 10090.ENSMUSP00000106361

UniGene: Mm.197460