Recombinant Mouse Alpha-1-antitrypsin 1-1 (Serpina1a)

中文名稱：

小鼠Serpina1a重組蛋白
貨號：

CSB-YP357195MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Serpina1a重組蛋白
貨號：

CSB-EP357195MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Serpina1a重組蛋白
貨號：

CSB-EP357195MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Serpina1a重組蛋白
貨號：

CSB-BP357195MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Serpina1a重組蛋白
貨號：

CSB-MP357195MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Serpina1a
Uniprot No.：

P07758
別名：

Serpina1a; Dom1; Spi1-1Alpha-1-antitrypsin 1-1; AAT; Alpha-1 protease inhibitor 1; Alpha-1-antiproteinase; Serine protease inhibitor 1-1; Serine protease inhibitor A1a; Serpin A1a
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

25-413
氨基酸序列

EDVQET DTSQKDQSPA SHEIATNLGD FAISLYRELV HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF NLTQTSEADI HKSFQHLLQT LNRPDSELQL STGNGLFVNN DLKLVEKFLE EAKNHYQAEV FSVNFAESEE AKKVINDFVE KGTQGKIAEA VKKLDQDTVF ALANYILFKG KWKKPFDPEN TEEAEFHVDE STTVKVPMMT LSGMLHVHHC STLSSWVLLM DYAGNATAVF LLPDDGKMQH LEQTLSKELI SKFLLNRRRR LAQIHFPRLS ISGEYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSQ AVHKAVLTID ETGTEAAAVT VLQMVPMSMP PILRFDHPFL FIIFEEHTQS PIFLGKVVDP THK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.
基因功能參考文獻：
1. Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation. PMID: 27515817
2. this study proved that SYVN1 enhances SERPINA1(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1(E342K)/ATZ cytotoxicity. PMID: 28121484
3. hAAT inhibits DC activation and function, and it also attenuates autoimmunity and renal damage in the MRL/lpr lupus model PMID: 27232337
4. FBG1 degrades A1AT-Z through a Beclin1-dependent arm of autophagy. PMID: 26295339
5. Data indicate that the scFv4B12 intrabody increased the secretion of Z alpha1-antitrypsin that retained inhibitory activity against neutrophil elastase. PMID: 25757566
6. unchecked neutrophil serine protease activity may arise from F. tularensis targeted reduction of plasma alpha(1)-antitrysin promoting lung tissue damage facilitating increased dissemination of this bacterium in infection PMID: 22919586
7. alpha-1 antitrypsin gene induction has a role in experimental and clinical acute kidney injury PMID: 24848503
8. A1AT bidirectional uptake and secretion from lung endothelial cells towards the alveolar epithelium and airspaces PMID: 24743137
9. oxidative stress is a contributing factor in the development of liver disease in this model of alpha-1-antitrypsin deficiency. PMID: 23104507
10. Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival PMID: 22949661
11. Data sshow that that plasmid-derived circulating hAAT protects islet allografts from acute rejection. PMID: 21670848
12. AAT represents a novel and viable strategy to mitigate clinical graft-versus-host disease by reducing serum levels of proinflammatory cytokines and altering the ratio of donor T effector to T regulatory cells in favor of reducing the pathological process. PMID: 22203983
13. Serpina1a serves a critical, nonredundant function during early mouse development. PMID: 21574874
14. analysis of the effect of mutant alpha1-antitrypsin on alpha1-antitrypsin deficiency PMID: 21505264
15. IL-8-induced hematopoietic stem cell mobilization is inhibited by serpina1 PMID: 16432201
16. Regulator of G Signaling 16 has a role in the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency PMID: 17635928
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亞細胞定位：

Secreted.
蛋白家族：

Serpin family
數據庫鏈接：

KEGG: mmu:20700

STRING: 10090.ENSMUSP00000072652

UniGene: Mm.439692