Recombinant Human Transcription factor HIVEP2 (HIVEP2), partial

中文名稱：

人HIVEP2重組蛋白
貨號：

CSB-YP010465HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人HIVEP2重組蛋白
貨號：

CSB-EP010465HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人HIVEP2重組蛋白
貨號：

CSB-EP010465HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人HIVEP2重組蛋白
貨號：

CSB-BP010465HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人HIVEP2重組蛋白
貨號：

CSB-MP010465HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

HIVEP2
Uniprot No.：

P31629
別名：

HIV EP2; HIV-EP2; HIVEP2; human immunodeficiency virus type I enhancer binding protein 2; Human immunodeficiency virus type I enhancer-binding protein 2; MBP 2; MBP-2; MHC binding protein 2; MHC-binding protein 2; MIBP1; SHN2; Transcription factor HIVEP2; ZAS2; ZEP2_HUMAN; ZNF40B
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
基因功能參考文獻：
1. Study provide further evidence that pathogenic variants in Human immunodeficiency virus type I enhancer binding protein 2 lead to intellectual disabilities and developmental delay. PMID: 27003583
2. HIVEP2 loss-of-function mutations were identified in intellectual disability patients. PMID: 26153216
3. The primary effect of MIBP1 (also known as HIVEP2) is the downregulation of the NF-kappaB pathway, and this effect is attenuated by O-GlcNAc signaling. PMID: 22294689
4. a 154-amino acid region of MIBP1 was necessary for its O-GlcNAc transferase binding and O-GlcNAcylation. PMID: 22294689
相關疾病：

Mental retardation, autosomal dominant 43 (MRD43)
亞細胞定位：

Nucleus.
組織特異性：

Expressed in brain and skeletal muscle.
數(shù)據(jù)庫鏈接：

HGNC: 4921

OMIM: 143054

KEGG: hsa:3097

STRING: 9606.ENSP00000012134

UniGene: Hs.510172