Recombinant Human Pre-mRNA-processing factor 6 (PRPF6), partial

中文名稱：

人PRPF6重組蛋白
貨號：

CSB-YP018772HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人PRPF6重組蛋白
貨號：

CSB-EP018772HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人PRPF6重組蛋白
貨號：

CSB-EP018772HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PRPF6重組蛋白
貨號：

CSB-BP018772HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人PRPF6重組蛋白
貨號：

CSB-MP018772HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PRPF6
Uniprot No.：

O94906
別名：

Androgen receptor N terminal domain transactivating protein 1; ANT 1; ANT1; C20orf14; hPrp6; p102 U5 small nuclear ribonucleoprotein particle binding protein; pre-mRNA processing factor 6; Pre-mRNA-processing factor 6; PRP6 homolog; PRP6 pre mRNA processing factor 6 homolog; PRP6_HUMAN; PRPF6; Putative mitochondrial outer membrane protein import receptor; TOM; U5 snRNP-associated 102 kDa protein; U5-102 kDa protein; U5-102K
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
基因功能參考文獻：
1. an essential role for PRPF6 in cancer via splicing of distinct growth-related gene products. PMID: 24788092
2. Our results identify PRPF6 as the sixth gene involved in pre-mRNA splicing and dominant RP, corroborating the hypothesis that deficiencies in the spliceosome play an important role in the molecular pathology of this disease. PMID: 21549338
3. The authors provide evidence that PRP6 and PRP31 are directly phosphorylated by human PRP4 kinase (PRP4K) concomitant with their incorporation into B complexes. PMID: 20118938
4. identification as a coactivator for the androgen receptor [p102 U5 small nuclear ribonucleoprotein particle-binding protein] PMID: 12039962
5. The interaction of CD2BP2 with a tri-snRNP bridging protein (Prp6), coupled with CD2BP2's absence from the tri-snRNP, suggests it might function in tri-snRNP assembly PMID: 15840814
6. C20orf14 may have a role in progression of lymphoma PMID: 18278469
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相關疾病：

Retinitis pigmentosa 60 (RP60)
亞細胞定位：

Nucleus, nucleoplasm. Nucleus speckle.
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 15860

OMIM: 613979

KEGG: hsa:24148

STRING: 9606.ENSP00000266079

UniGene: Hs.31334