Recombinant Human Myocyte-specific enhancer factor 2C (MEF2C)

中文名稱：

Recombinant Human Myocyte-specific enhancer factor 2C (MEF2C)
品名簡稱：

Recombinant Human MEF2C protein
貨號：

CSB-EP804958HUf2
說明書：

MSDS Datasheet
規格：

￥1536
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

MEF2C
Uniprot No.：

Q06413
別名：

Myocyte enhancer factor 2C
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

E.coli
分子量：

52.4 kDa
表達區域：

1-473aa
氨基酸序列

MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal Flag-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1.
基因功能參考文獻：
1. This study indicates MEF2C as a new gene responsible for human dilated cardiomyopathy (DCM), which provides novel insight into the mechanism underpinning DCM, suggesting potential implications for development of innovative prophylactic and therapeutic strategies for DCM, the most prevalent form of primary myocardial disease. PMID: 28902616
2. Overexpression of MEF2C decreased miR-448-induced VSMCs proliferation and migration. PMID: 28799067
3. MEF2C mRNA expression levels in AD subjects are significantly lower than those in control subjects and are correlated with disease severity. PMID: 29112298
4. The regulation mechanism of MIG6 and suggests potential implications for the therapeutic strategies of gefitinib resistance through inhibiting MEF2C in hepatic cancer cells. PMID: 29714661
5. This study firstly associates MEF2C loss-of-function mutation with double outlet right ventricle in humans, which provides novel insight into the molecular pathogenesis of congenital heart diseases. PMID: 29468350
6. Combined with automated 2D nano-scale chromatography, Accumulated ion monitoring achieved subattomolar limits of detection of endogenous proteins in complex biological proteomes. This allowed quantitation of absolute abundance of the human transcription factor MEF2C at approximately 100 molecules/cell, and determination of its phosphorylation stoichiometry from as little as 1 mug of extracts isolated from 10,000 human ... PMID: 28821601
7. the mutation significantly diminished the synergistic activation between MEF2C and GATA4, another cardiac core transcription factor that has been causally linked to Congenital heart disease (CHD). PMID: 29104469
8. MEF2C expression levels were significantly associated with or may even be predictive of the response to glucocorticoid treatment. PMID: 28482719
9. MEF2C rs190982 polymorphism has a role in late-onset Alzheimer's disease in Han Chinese PMID: 27276684
10. MEF2C mRNA level is up-regulated in both sporadic and SOD1 + ALS patients. PMID: 26921792
11. a MEF2C and CEBPA correlation in CML disease progression PMID: 27297623
12. Single nucleotide polymorphism in MEF2C gene is associated with major depressive disorder. PMID: 27479909
13. we identified novel associations in WLS , ARHGAP1 , and 5' of MEF2C ( P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly associated with BMD compared to the GWAS SNPs. PMID: 27616567
14. Our analysis consistently identified significant sub-networks associated with the interacting transcription factors MEF2C and TWIST1, genes not previously associated with spontaneous preterm births , both of which regulate processes clearly relevant to birth timing. PMID: 27664809
15. Key role for miR-214 in modulation of MEF2C-MYOCD-LMOD1 signaling. PMID: 27144530
16. Endothelial Mef2c regulates the endothelial actin cytoskeleton and inhibits smooth muscle cell migration into the intima. PMID: 28473437
17. The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients PMID: 27907007
18. Findings suggest that a single introduction of the three cardiomyogenic transcription factor (GATA4, cand TBX5)genes using polyethyleneimine (PEI)-based transfection is sufficient for transdifferentiation of adipose-derived stem cells (hADSCs) towards the cardiomyogenic lineage. PMID: 27553283
19. Mef2c is highly expressed in the retina where it modulates photoreceptor-specific gene expression PMID: 28017720
20. Study provides evidence that Mef2c cooperated with Sp1 to activate human AQP1 transcription by binding to its proximal promoter in human umbilical cord vein endothelial cells indicating that AQP1 is a direct target of Mef2c in regulating angiogenesis and vasculogenesis of endothelial cells. PMID: 26923194
21. Data show that microRNA miR-27a was essential for the shift of mesenchymal stem cells (MSCs) from osteogenic differentiation to adipogenic differentiation in osteoporosis by targeting myocyte enhancer factor 2 c (Mef2c). PMID: 27337099
22. New MEF2C mutation in MEF2C haploinsufficiency syndrome PMID: 27255693
23. Long non-coding RNA uc.167 influences cell proliferation, apoptosis and differentiation of P19 cells by regulating Mef2c. PMID: 27268728
24. We describe the prenatal identification of 5q14.3 duplication, including MEF2C, in a monochorionic twin pregnancy with corpus callosum anomalies, confirmed by autopsy. To the best of our knowledge, this cerebral finding has been observed for the first time in 5q14.3 duplication patients, possibly widening the neurological picture of this scarcely known syndrome. A pathogenetic role of MEF2C overexpression in brain develop PMID: 26864752
25. The finding of a jugular pit in this patient facilitated the diagnosis, and he is, to our knowledge, the third case of jugular pit in association with 5q14.3 deletion incorporating the MEF2C locus. PMID: 26426104
26. MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and Migration in Atherosclerosis by Directly Targeting MEF2C PMID: 26184978
27. early B cell factor-1 (EBF1) was identified as a co-regulator of gene expression with MEF2C. PMID: 26900922
28. Data show that high myocyte enhancer factor 2C (MEF2C) mRNA expression leads to overexpression of MEF2C protein, and these findings provide the rationale for therapeutic targeting of MEF2C transcriptional activation in acute myeloid leukemia. PMID: 26487643
29. this is the first report of a Greek-Cypriot patient with a MEF2C-related phenotype highlighting the rich variability in phenotypic expression and the ethnic diversity associated with this condition. PMID: 25691421
30. BCL2 inhibitors may be a therapeutic candidate in vivo for patients with ETP-ALL with high expression levels of MEF2C. PMID: 26172269
31. MEF2C regulates the expression of G2/M checkpoint genes (14-3-3gamma, Gadd45b and p21) and the sub-cellular localization of CYCLIN B1. PMID: 25789873
32. The overall effect of MEF2C in hepatocellular carcinoma progression regulation was dictated by its subcellular distribution. PMID: 25328135
33. MEF2C/alpha-2-macroglobulin axis functions in endothelial cells as a negative feed-back mechanism that adapts sprouting activity to the oxygen concentration thus diminishing inappropriate and excess angiogenesis. PMID: 24988463
34. MEF2C and MEF2D interact with the E3 ligase F-box protein SKP2, which mediates their subsequent degradation through the ubiquitin-proteasome system. PMID: 25733682
35. Single nucleotide polymorphisms in ALDOB, MAP3K1, and MEF2C are associated with cataract. PMID: 25352737
36. Alternative splicing of the alpha-exon of MEF2C regulates myogenesis. PMID: 25404735
37. Combinations that resulted in higher protein levels of Mef2c enhanced reprogramming efficiency of cardiac myocytes. PMID: 25416133
38. MEF2C binding in inflammatory pathways is associated with its role in bone density PMID: 24337390
39. We identified MEF2C as a novel transcription factor that regulates Nampt expression through specific interaction sites at the promoter; its regulatory role was highly dependent on epigenetic modulations, especially under hypoxia conditions PMID: 23888946
40. MEF2 regulatory network is disrupted in myotonic dystrophy cardiac tissue leading to altered expression of a large number of miRNA and mRNA targets. PMID: 24412363
41. Results identify redox-mediated protein posttranslational modifications, including S-nitrosylation and sulfonation of a critical cysteine residue in MEF2, as an early event contributing to neuronal damage in Parkinson's disease induced by mitochondrial toxins. PMID: 24290359
42. variants at MEF2C were associated with forearm bone mineral density (BMD), implicating this gene in the determination of BMD at forearm. [meta-analysis] PMID: 23572186
43. One variant, rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene, was associated with retinal arteriolar caliber in meta-analysis. PMID: 23776548
44. MEF2C alpha- variants are significantly expressed during neuronal cell differentiation, indicating a putative role of these variants in development. PMID: 24008018
45. Validated miR-223 targets MEF2C and PTBP2 were significantly upregulated in chronic myeloid leukemia samples. PMID: 23174904
46. Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart. PMID: 23468913
47. A targeted search for MEF2C mutations could be applied to patients with a severe intellectual deficiency associated with absence of language and hypotonia, strabismus, and epilepsy. PMID: 23001426
48. genetic association study in population of 1,012 Han women in China: Data suggest that an SNP in MEF2C (rs1366594) is associated with bone mineral density of lumbar spine and hip joint in aging women. PMID: 22798246
49. SREBP-1 regulate muscle protein synthesis through the downregulation of the expression of MYOD1, MYOG and MEF2C factors. PMID: 23226416
50. Mutations in MEF2C are probably a very rare cause of Rett syndrome. PMID: 22449245
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相關疾病：

Mental retardation, autosomal dominant 20 (MRD20)
亞細胞定位：

Nucleus. Cytoplasm, sarcoplasm.
蛋白家族：

MEF2 family
組織特異性：

Expressed in brain and skeletal muscle.
數據庫鏈接：

HGNC: 6996

OMIM: 600662

KEGG: hsa:4208

UniGene: Hs.649965