Recombinant Human Leucine carboxyl methyltransferase 2 (LCMT2)

中文名稱：

人LCMT2重組蛋白
貨號：

CSB-YP012809HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人LCMT2重組蛋白
貨號：

CSB-EP012809HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人LCMT2重組蛋白
貨號：

CSB-EP012809HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人LCMT2重組蛋白
貨號：

CSB-BP012809HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人LCMT2重組蛋白
貨號：

CSB-MP012809HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

LCMT2
Uniprot No.：

O60294
別名：

KIAA0547; LCMT 2; Lcmt2; LCMT2_HUMAN; Leucine carboxyl methyltransferase 2; MGC9534; p21WAF1/CIP1 promoter interacting protein; p21WAF1/CIP1 promoter-interacting protein; PPM2; tRNA Wybutosine synthesizing protein 4; tRNA wybutosine synthesizing protein 4 homolog; tRNA wybutosine-synthesizing protein 4 homolog; tRNA yW synthesizing protein 4; tRNA yW synthesizing protein 4 homolog; tRNA yW-synthesizing protein 4 homolog; TYW4
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-686
氨基酸序列

MGPRSRERRA GAVQNTNDSS ALSKRSLAAR GYVQDPFAAL LVPGAARRAP LIHRGYYVRA RAVRHCVRAF LEQIGAPQAA LRAQILSLGA GFDSLYFRLK TAGRLARAAV WEVDFPDVAR RKAERIGETP ELCALTGPFE RGEPASALCF ESADYCILGL DLRQLQRVEE ALGAAGLDAA SPTLLLAEAV LTYLEPESAA ALIAWAAQRF PNALFVVYEQ MRPQDAFGQF MLQHFRQLNS PLHGLERFPD VEAQRRRFLQ AGWTACGAVD MNEFYHCFLP AEERRRVENI EPFDEFEEWH LKCAHYFILA ASRGDTLSHT LVFPSSEAFP RVNPASPSGV FPASVVSSEG QVPNLKRYGH ASVFLSPDVI LSAGGFGEQE GRHCRVSQFH LLSRDCDSEW KGSQIGSCGT GVQWDGRLYH TMTRLSESRV LVLGGRLSPV SPALGVLQLH FFKSEDNNTE DLKVTITKAG RKDDSTLCCW RHSTTEVSCQ NQEYLFVYGG RSVVEPVLSD WHFLHVGTMA WVRIPVEGEV PEARHSHSAC TWQGGALIAG GLGASEEPLN SVLFLRPISC GFLWESVDIQ PPITPRYSHT AHVLNGKLLL VGGIWIHSSS FPGVTVINLT TGLSSEYQID TTYVPWPLML HNHTSILLPE EQQLLLLGGG GNCFSFGTYF NPHTVTLDLS SLSAGQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
基因功能參考文獻：
1. Kr-pok interacted directly with the DNA binding and oligomerization domains of p53. This interaction was essential for Kr-pok to bind the distal promoter region of the CDKN1A gene, p21WAF1, and to inhibit p53-mediated transcriptional activation of CDKN1A. PMID: 22253232
2. This paper reports crystal structures of a yeast homolog, TYW4. PMID: 19287006
3. Cigarette smoke-induced oxidative stress and TGF-beta1 increase its expression in alveolar epithelial cells PMID: 12485877
4. Inacativaton of this cell cycle regulatory genes by DNA methylation could be associated with tumorigenesis in NK cell disorders. PMID: 15813917
5. p21WAF1 and Bax may be used as the markers in the assessment of GIST malignant potential. PMID: 16830365
6. In conclusion, we report that the transcription factor Sp1 involved in the p38MAPK-mediated control of p21WAF1 regulation on VSMC in response to BITC has now been identified. PMID: 17026958
顯示更多

收起更多
蛋白家族：

Methyltransferase superfamily, LCMT family
數據庫鏈接：

HGNC: 17558

OMIM: 611246

KEGG: hsa:9836

STRING: 9606.ENSP00000307214

UniGene: Hs.200596