Recombinant Human Inactive phospholipase C-like protein 1 (PLCL1), partial

中文名稱：

人PLCL1重組蛋白
貨號：

CSB-YP624015HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人PLCL1重組蛋白
貨號：

CSB-EP624015HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人PLCL1重組蛋白
貨號：

CSB-EP624015HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PLCL1重組蛋白
貨號：

CSB-BP624015HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人PLCL1重組蛋白
貨號：

CSB-MP624015HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PLCL1
Uniprot No.：

Q15111
別名：

Inactive phospholipase C-like protein 1; Inactive protein 1; Phospholipase C deleted in lung carcinoma; Phospholipase C epsilon; Phospholipase C like 1; Phospholipase C related but catalytically inactive protein; Phospholipase C related, but catalytically inactive protein; Phospholipase C-deleted in lung carcinoma; Phospholipase C-related but catalytically inactive protein; Phospholipase C-related catalytically; PLC-L1; PLCE; PLCL; PLCL1; PLCL1_HUMAN; PLDL1; PRIP
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
基因功能參考文獻：
1. susceptibility gene for dermatomyositis in Chinese patients with idiopathic inflammatory myopathies PMID: 26603167
2. PRIP interacts with the catalytic subunits of PP1 and PP2A and the interactions are regulated by phosphorylation. [review] PMID: 23911386
3. effect of DZP on PRIP-1 knockout mice was reduced PMID: 22128345
4. In postmenopausal women, our results suggest that the PLCL1 rs7595412 polymorphism has no obvious effect on hip bone size and bone mineral density but may be associated with increased proportion of vertebral fracture and increased levels of osteocalcin PMID: 20030815
5. PRIP-1 plays an important role in type A receptor signaling for gamma-aminobutyric acid in the brain PMID: 16952428
6. PLCL1 is a novel gene associated with variation in hip bone size, which has a role in the pathogenesis of hip fractures PMID: 18776929
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亞細胞定位：

Cytoplasm.
組織特異性：

Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.
數據庫鏈接：

HGNC: 9063

OMIM: 600597

KEGG: hsa:5334

STRING: 9606.ENSP00000402861

UniGene: Hs.153322