Recombinant Human Actin-related protein 2/3 complex subunit 3 (ARPC3)

中文名稱：

Recombinant Human Actin-related protein 2/3 complex subunit 3(ARPC3)
貨號：

CSB-YP002128HU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Actin-related protein 2/3 complex subunit 3(ARPC3)
貨號：

CSB-EP002128HU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Actin-related protein 2/3 complex subunit 3(ARPC3)
貨號：

CSB-EP002128HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Actin-related protein 2/3 complex subunit 3(ARPC3)
貨號：

CSB-BP002128HU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Actin-related protein 2/3 complex subunit 3(ARPC3)
貨號：

CSB-MP002128HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ARPC3
Uniprot No.：

O15145
別名：

ARPC3; ARC21Actin-related protein 2/3 complex subunit 3; Arp2/3 complex 21 kDa subunit; p21-ARC
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-178
氨基酸序列

PAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI TNFPIPGEPG FPLNAIYAKP ANKQEDEVMR AYLQQLRQET GLRLCEKVFD PQNDKPSKWW TCFVKRQFMN KSLSGPGQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
基因功能參考文獻：
1. Cancer cell motility mediated by the actin-related protein 2/3 complex (Arp2/3) is required for vessel co-option in liver metastases in vivo. PMID: 27748747
2. genetic association study in population in Canada: Data suggest that an SNP in the promoter region of ARPC3 (CpG-SNP rs3759384 C>T) is associated with metabolic syndrome complicated by severe abdominal obesity and hypertriglyceridemia in the population studied. PMID: 27055012
3. Endogenous Nogo-B, which may exert its effects through ARPC 2/3 and MYL-9, is necessary for the migration and contraction of airway smooth muscle cells. PMID: 21251247
4. The actin-related protein 3 structures were more visible with anti-p34Arc monoclonal antibody. PMID: 15793564
亞細胞定位：

Cytoplasm, cytoskeleton. Cell projection. Nucleus.
蛋白家族：

ARPC3 family
數據庫鏈接：

HGNC: 706

OMIM: 604225

KEGG: hsa:10094

STRING: 9606.ENSP00000228825

UniGene: Hs.524741