Recombinant Human AP-3 complex subunit beta-2 (AP3B2), partial

中文名稱：

Recombinant Human AP-3 complex subunit beta-2(AP3B2) ,partial
貨號：

CSB-YP621662HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human AP-3 complex subunit beta-2(AP3B2) ,partial
貨號：

CSB-EP621662HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human AP-3 complex subunit beta-2(AP3B2) ,partial
貨號：

CSB-BP621662HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human AP-3 complex subunit beta-2(AP3B2) ,partial
貨號：

CSB-MP621662HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

AP3B2
Uniprot No.：

Q13367
別名：

Adapter-related protein complex 3 subunit beta-2; Adaptor protein complex AP-3 subunit beta-2; Adaptor related protein complex 3 beta 2 subunit; AP 3 complex subunit beta 2; AP-3 complex subunit beta-2; AP3B2; AP3B2_HUMAN; beta NAP; Beta-3B-adaptin; Beta3B adaptin; Beta3b; Clathrin assembly protein complex 3 beta 2 large chain; Clathrin assembly protein complex 3 beta-2 large chain; NAPTB; Neuron specific vesicle coat protein and cerebellar degeneration antigen; Neuron-specific vesicle coat protein beta-NAP; Neuronal adaptin like protein beta subunit
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
基因功能參考文獻：
1. Autosomal-Recessive Mutations in AP3B2, Adaptor-Related Protein Complex 3 Beta 2 Subunit, Cause an Early-Onset Epileptic Encephalopathy with Optic Atrophy. PMID: 27889060
2. Our findings provide direct evidence for the association of FBXO38 and AP3B2 with severe chronic periodontitis in the Han Chinese population. PMID: 26643602
3. A novel splice variant of AP3B2, AP3B2_v2, was isolated by large-scale sequencing analysis of a fetal brain cDNA library; Sequence analysis showed AP3B2_v2 missed 22 exons that existed in AP3B2_upsilon1, encoding a different putative protein PMID: 17453999
相關疾病：

Epileptic encephalopathy, early infantile, 48 (EIEE48)
亞細胞定位：

Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus.
蛋白家族：

Adaptor complexes large subunit family
組織特異性：

Isoform 1 expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deepe
數(shù)據(jù)庫鏈接：

HGNC: 567

OMIM: 602166

KEGG: hsa:8120

STRING: 9606.ENSP00000261722

UniGene: Hs.199593