Recombinant Bovine Cathepsin B (CTSB)

中文名稱：

Recombinant Bovine Cathepsin B(CTSB)
貨號：

CSB-YP006185BO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Bovine Cathepsin B(CTSB)
貨號：

CSB-EP006185BO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Bovine Cathepsin B(CTSB)
貨號：

CSB-EP006185BO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Bovine Cathepsin B(CTSB)
貨號：

CSB-BP006185BO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Bovine Cathepsin B(CTSB)
貨號：

CSB-MP006185BO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

CTSB
Uniprot No.：

P07688
別名：

CTSB; Cathepsin B; EC 3.4.22.1; BCSB) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]
種屬：

Bos taurus (Bovine)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

80-332
氨基酸序列

L PESFDAREQW PNCPTIKEIR DQGSCGSCWA FGAVEAISDR ICIHSNGRVN VEVSAEDMLT CCGGECGDGC NGGFPSGAWN FWTKKGLVSG GLYNSHVGCR PYSIPPCEHH VNGSRPPCTG EGDTPKCSKT CEPGYSPSYK EDKHFGCSSY SVANNEKEIM AEIYKNGPVE GAFSVYSDFL LYKSGVYQHV SGEIMGGHAI RILGWGVENG TPYWLVGNSW NTDWGDNGFF KILRGQDHCG IESEIVAGMP CT
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis.
基因功能參考文獻(xiàn)：
1. The cathepsin B deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease. PMID: 21585286
2. evidence shows cathepsin B activity may not be redox regulated; however, the stability of the enzyme at neutral pH is dependent on redox potential, and on the presence of oxidising agents. PMID: 12437106
3. Overexpressing cathepsin B reduced the Vascular Endothelial Growth Factor-dependent tube response PMID: 15901832
4. The peptides, all of which contain a C-terminal free acid, were tested as inactivators of bovine cathepsin B, in an attempt at exploiting the known and, amongst the cysteine proteinases, unique carboxy dipeptidyl peptidase activity of the protease. PMID: 15978544
亞細(xì)胞定位：

Lysosome. Melanosome. Secreted, extracellular space. Apical cell membrane; Peripheral membrane protein; Extracellular side.
蛋白家族：

Peptidase C1 family
組織特異性：

Expressed in myoblasts, the myotube, fibroblasts and fetal muscle (at protein level). Expressed in the spleen (at protein level).
數(shù)據(jù)庫鏈接：

KEGG: bta:281105

STRING: 9913.ENSBTAP00000036650

UniGene: Bt.393