SVBP Antibody, FITC conjugated

說(shuō)明書(shū)

產(chǎn)品詳情

產(chǎn)品名稱(chēng)：

Rabbit anti-Homo sapiens (Human) SVBP Polyclonal antibody
Uniprot No.：

Q8N300
基因名：

SVBP
別名：

SVBP antibody; CCDC23 antibody; Small vasohibin-binding protein antibody; Coiled coil domain-containing protein 23 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Small vasohibin-binding protein (1-66AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

FITC
克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation.
基因功能參考文獻(xiàn)：
1. identified a novel UPS regulatory system in which essential domain architecture (VASH-PS) of VASHs, comprising regions VASH191-180 and VASH280-169 , regulate the cytosolic punctate structure formation in the absence of SVBP. PMID: 27879017
2. VASH2 contributes to the angiogenesis in hepatocellular carcinoma via an SVBP-mediated paracrine mechanism. PMID: 22614011
3. SVBP(CCDC23)acts as a secretory chaperone for VASH1. PMID: 20736312
亞細(xì)胞定位：

Cytoplasm. Secreted. Cytoplasm, cytoskeleton.
蛋白家族：

SVBP family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 29204

OMIM: 617853

KEGG: hsa:374969

STRING: 9606.ENSP00000361599

UniGene: Hs.113919

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