ST8SIA2 Antibody

說明書

中文名稱：

ST8SIA2兔多克隆抗體
貨號：

CSB-PA852840ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: Alpha-2, 8-sialyltransferase 8B antibody at 8μg/ml
Lane 1: Mouse heart tissue
Lane 2: HepG2 whole cell lysate
Lane 3: Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 42 kDa
Observed band size: 42 kDa

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA852840ESR2HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA852840ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ST8SIA2 Polyclonal antibody
Uniprot No.：

Q92186
基因名：

ST8SIA2
別名：

ST8SIA2 antibody; SIAT8B antibody; STX antibody; Alpha-2,8-sialyltransferase 8B antibody; EC 2.4.99.- antibody; Sialyltransferase 8B antibody; SIAT8-B antibody; Sialyltransferase St8Sia II antibody; ST8SiaII antibody; Sialyltransferase X antibody; STX antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Alpha-2,8-sialyltransferase 8B protein (24-160AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.
基因功能參考文獻：
1. The ST8SIA2 risk haplotype copy number did not show any differential effects on white matter in schizophrenia. PMID: 29353880
2. impairment of the regulated expression of ST8SIA2 and the resulting downstream effects on gene products by these two intronic single nucleotide polymorphism contribute to the development of these psychiatric disorders. PMID: 27565727
3. ST8SiaII role in the invasiveness and metastasis of small cell lung cancer cells PMID: 28004110
4. the relationships between psychiatric disorders and polySia and/or ST8SIA2 PMID: 27105834
5. Data indicate a possible role of STX polysialyltransferase (ST8SIA2) in the common susceptibility of schizophrenia and bipolar I disorder (BD-I). PMID: 26418860
6. Our study showed interesting sex-specific associations between ST8SIAII and schizophrenia. PMID: 24070986
7. the role of ST8SIA2 sequence variation affecting polysialic acid-NCAM formation in 48 Caucasian cases with bipolar disorder PMID: 24651862
8. translational modification of the neural cell adhesion molecule NCAM and the polysialyltransferase ST8SiaII in mammalian semen involves polysialic acid PMID: 23671285
9. Expression of ST8SIA2 in omental fat at baseline was significantly associated with weight loss after Roux-en-Y gastric bypass. PMID: 23643386
10. that variation the ST8SIA2 gene is associated with increased risk to mental illness PMID: 22693595
11. NCAM and polySia are expressed and developmentally regulated in chick corneas. Both membrane-associated and soluble NCAM isoforms are expressed in chick corneas. PMID: 22281821
12. ST8SIA2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
13. STX(G421A) shows a dramatic decrease in polySia synthetic activity on NCAM, whereas STX(C621G) does not; polySia shows a dopamine (DA) binding activity PMID: 21464126
14. This study provided that ST8SIA2 are associated with Bipolar I in the Han Chinese population. PMID: 20386566
15. SIAT8B has a role in neural development and sialic acid synthesis on NCAM PMID: 12138100
16. SIAT8B gene is involved in schizophrenia in the Japanese. PMID: 16229822
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亞細胞定位：

Golgi apparatus membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase 29 family
組織特異性：

Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus.
數據庫鏈接：

HGNC: 10870

OMIM: 602546

KEGG: hsa:8128

STRING: 9606.ENSP00000268164

UniGene: Hs.302341

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