SLCO1A2 Antibody
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中文名稱：SLCO1A2兔多克隆抗體
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貨號：CSB-PA983558
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HepG2 cells, MCF-7 cells and HeLa cells, using SLCO1A2 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SLCO1A2 Polyclonal antibody
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Uniprot No.：
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基因名：SLCO1A2
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human SLCO1A2.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. Selectively inhibited by the grapefruit juice component naringin.
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基因功能參考文獻：
- Our findings uncover novel associations of progressive supranuclear palsy with SLCO1A2 (rs11568563) and DUSP10 (rs6687758) variants PMID: 29986742
- The binding site may be responsible in part for the suppression effect of TNFalpha towars SLCO1A2 expression. PMID: 29549185
- SLCO1A2 and SLCO1B1 gene treatment over time interactions were associated with gametocytemia clearance rate. PMID: 28975866
- OATP1A2, OATP1B1, and OATP2B1 can mediate cellular uptake of ochratoxin A, which could aggravate OTA toxicity. PMID: 28532671
- important roles for OATP1A/1B in transporter-mediated uptake and disposition of doxorubicin, are reported. PMID: 27777271
- data provide the implication of UGT1A1 and SLCO1A2 in sickle cell anemia-related cholelithiasis. PMID: 26146896
- Genetic polymorphisms and function of the OATP1A2 and its clinical relevance in drug disposition PMID: 25924632
- Report OATP1A2 expression in human retinal pigmented epithelial cells and suggest role in cellular uptake of all-trans retinol. PMID: 25560245
- analysis of how the transmembrane domain 6 of the human organic anion transporting polypeptide 1A2 (OATP1A2) influences transporter substrate binding, protein trafficking, and quality control PMID: 25387129
- PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability. PMID: 24728453
- Combined high OATP1A2/high OCT6 may be a potential predictor of response to anthracycline/taxane-based chemotherapy in breast cancer PMID: 24671357
- human OATP1B1, OATP1B3 and OATP1A2 can transport docetaxel in vivo. PMID: 24825069
- Five novel single nucleotide polymorphisms (SNIP)S in the coding exons of SLCO1A2 gene transporter have been identified. PMID: 23918469
- Human OATP1A/1B transporters play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutics methotrexate and paclitaxel PMID: 23243220
- results suggest that enhanced OATP1A2 expression is associated with adaptive cell growth of prostate cancer cells under androgen-depleted conditions PMID: 22864060
- Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier. PMID: 22509823
- SLCO1A2 promoter variant 1 was strongly induced by vitamin D receptor. PMID: 22474172
- The expression of OATP1A2 and OATP1B3 in placenta decreased in, and may be involved in the pathophysiology of, intrahepatic cholestasis of pregnancy. OATP1A2 was localized to the vasculo-syncytial membrane and apical surface of syncytiotrophoblasts. PMID: 22203093
- Data suggest that inhibition of OATP1A2 in intestinal mucosa at least partially explains effects of grapefruit juice (or grapefruit juice components such as the flavonoid naringin) on pharmacokinetics of aliskiren, an antihypertensive agent. PMID: 22124880
- Digoxin inhibited the uptake of probe substrates of OATP1B1 (IC(50) of 47 muM), OATP1B3 (IC(50) > 8.1 muM), and OATP2B1 (IC(50) > 300 muM), but not OATP1A2 in transfected cell lines. PMID: 21849517
- protein kinase C(PKC) regulates the transport function of OATP1A2 by modulating protein internalization; this effect of PKC is mediated in part by clathrine-dependent pathways PMID: 21133891
- SLCO1A2 polymorphisms significantly affect imatinib pharmacokinetics. PMID: 21633340
- Although imatinib is indicated as a substrate for OATP1A2, this transporter by itself is unlikely to contribute substantially to the absorption profiles of imatinib in humans. PMID: 21508937
- data suggest that among the many known transporters common variations of PXR, SLCO1A2, SLCO1B1, SLCO1B3, and SLCO2B1 do not contribute to breast carcinogenesis PMID: 20635135
- Is present in high frequencies in the finnish population PMID: 20560925
- By using the presence of bilirubin as a phenotype, variants rs6742078 (UGT1A1; P = .003), rs4149056 (SLCO1B1; P = .003), and rs4149000 (SLCO1A2; P = .015) were associated with gallstone composition PMID: 20837016
- Antiretroviral protease inhibitors, but not non-nucleoside reverse transcriptase inhibitors, are substrates for OATP1A2, OATP1B1 and OATP1B3. PMID: 20051929
- SLCO1A2 polymorphisms may be an important yet unrecognized contributor to inter-individual variability in drug disposition and central nervous system entry of substrate drugs. PMID: 15632119
- a potentially important role for OATP-A in the absorption and disposition of saquinovir in vivo. PMID: 15832500
- Review summarizes current knowledge on the functional and phenotypic consequences of genetic variation in intestinally, hepatically and renally expressed members of the organic anion-transporting polypeptide (OATP) family. PMID: 18466105
- the interplay between a xenobiotic nuclear receptor PXR and OATP1A2 that could contribute to the pathogenesis of breast cancer. PMID: 19010908
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：Organo anion transporter (TC 2.A.60) family
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數據庫鏈接：
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