PTK2 Antibody, FITC conjugated

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說明書

中文名稱：

PTK2兔多克隆抗體, FITC偶聯
貨號：

CSB-PA14445C0Rb
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Chicken PTK2 Polyclonal antibody
Uniprot No.：

Q00944
基因名：

PTK2
別名：

PTK2 antibody; FAK antibody; FAK1 antibody; Focal adhesion kinase 1 antibody; FADK 1 antibody; EC 2.7.10.2 antibody; Focal adhesion kinase-related nonkinase antibody; FRNK antibody; p41/p43FRNK antibody; Protein-tyrosine kinase 2 antibody; p125FAK antibody; pp125FAK antibody
宿主：

Rabbit
反應種屬：

Chicken
免疫原：

Recombinant Chicken Focal adhesion kinase 1 protein (376-683AA)
免疫原種屬：

Chicken
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Regulates P53/TP53 activity and stability. Phosphorylates SRC; this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling.
基因功能參考文獻：
1. FAK-derived peptide binds the SH3 domain in two orientations. PMID: 26645346
2. findings uncover an inhibitory interaction between the FAK FERM domain and sarcomeric myosin that presents potential opportunities to modulate the cardiac hypertrophic response through changes in FAK activity PMID: 22101605
3. Src-dependent FAK phosphorylation is required for focal adhesion turnover and cell migration PMID: 15340073
4. structural features suggest the possibility that protein interactions of the FAK FERM domain can be regulated by binding of Src kinases to the linker segment PMID: 16221668
5. inactivation of p38MAPK down-regulated the level of MMP-2 mRNA and activity, and increased mesenchymal cell condensation in parallel with enhanced phosphorylation of FAK PMID: 17604018
6. These data suggested that the apoptotic effect of transforming growth factor-beta1 on satellite cells is likely associated with a beta1 integrin-mediated focal adhesion kinase signaling pathway. PMID: 19590089
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亞細胞定位：

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, cilium basal body.
蛋白家族：

Protein kinase superfamily, Tyr protein kinase family, FAK subfamily
數據庫鏈接：

KEGG: gga:396416

STRING: 9031.ENSGALP00000026014

UniGene: Gga.15614

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