MYOZ2 Antibody

中文名稱：

MYOZ2兔多克隆抗體
貨號：

CSB-PA873609LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: MYOZ2 antibody at 4.31µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 30 kDa
Observed band size: 30 kDa

IHC image of CSB-PA873609LA01HU diluted at 1:300 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA873609LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MYOZ2 Polyclonal antibody
Uniprot No.：

Q9NPC6
基因名：

MYOZ2
別名：

C4orf5 antibody; Calcineurin binding protein calsarcin 1 antibody; Calsarcin 1 antibody; Calsarcin-1 antibody; Calsarcin1 antibody; CMH16 antibody; CS 1 antibody; CS1 antibody; FATZ related protein 2 antibody; FATZ-related protein 2 antibody; Muscle specific protein antibody; MYOZ 2 antibody; MYOZ2 antibody; MYOZ2_HUMAN antibody; Myozenin-2 antibody; Myozenin2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Myozenin-2 protein (90-180AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MYOZ2 Antibody (CSB-PA873609LA01HU)，的標記方式是Non-conjugated。對于MYOZ2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA873609LB01HU	MYOZ2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA873609LC01HU	MYOZ2 Antibody, FITC conjugated
Biotin	CSB-PA873609LD01HU	MYOZ2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
基因功能參考文獻：
1. may play a modifying role in hypertrophic cardiomyopathy by affecting the penetrance or degree of performance of the MYH7 gene PMID: 28296734
2. The cardiac phenotype in hypertrophic cardiomyopathy caused by MYOZ2 mutations might be independent of calcineurin activity in the heart. PMID: 22987565
3. Two missense mutations, S48P substitution and I246M affecting highly conserved amino acids were linked to hereditary Hypertrophic cardiomyopathy characterized by early onset of symptoms, pronounced cardiac hypertrophy, and cardiac arrhythmias. PMID: 17347475
4. Mutations in MYOZ1 and MYOZ2 are at least very rare events as an underlying disease mechanism for idiopathic or familial DCM PMID: 17434779
5. Observational study of genotype prevalence. (HuGE Navigator) PMID: 17347475
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相關疾病：

Cardiomyopathy, familial hypertrophic 16 (CMH16)
亞細胞定位：

Cytoplasm, myofibril, sarcomere, Z line.
蛋白家族：

Myozenin family
組織特異性：

Expressed specifically in heart and skeletal muscle.
數據庫鏈接：

HGNC: 1330

OMIM: 605602

KEGG: hsa:51778

STRING: 9606.ENSP00000306997

UniGene: Hs.732122

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