IFRD1 Antibody，Biotin conjugated
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中文名稱：IFRD1兔多克隆抗體，Biotin偶聯
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貨號：CSB-PA011069LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) IFRD1 Polyclonal antibody
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Uniprot No.：
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基因名：IFRD1
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別名：12 O tetradecanoylphorbol 13 acetate induced sequence 7 antibody; IFRD1 antibody; IFRD1_HUMAN antibody; interferon related developmental regulator 1 antibody; Interferon-related developmental regulator 1 antibody; Nerve growth factor inducible protein PC4 antibody; Nerve growth factor-inducible protein PC4 antibody; PC4 antibody; Pheochromocytoma cell 4 antibody; TIS7 antibody; TPA induced sequence 7 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Interferon-related developmental regulator 1 protein (1-200AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Antigen Affinity purified & Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal.
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基因功能參考文獻：
- Results from a study on gene expression variability markers in early-stage human embryos shows that IFRD1 is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
- High IFRD1 colon cancer expression was significantly associated with decreased 5-year patient survival. PMID: 29094309
- this study shows that IFRD1 gene may be associated with pathogenesis of asthma PMID: 27842724
- rs7817 polymorphism associated with nasal polyposis in cystic fibrosis patients PMID: 26397160
- study reveals an EGFR-IFRD1-mediated viral immune evasion mechanism, which can also be exploited by cancer cells PMID: 26055519
- rs5009270 may contribute to hip OA susceptibility by altering proximal femur shape. PMID: 25939412
- PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta. PMID: 25308091
- Studied the association between IFRD1 polymorphisms and gastric cancer in a Chinese population. PMID: 25073439
- IFRD1 expression is systemically up-regulated in CF neutrophils, is linked to the production of ROS, and is modulated by chemokines in CF airway fluids, depending on the IFRD1 genotype. PMID: 23043087
- This work provides evidence for the first time of reduced level of IFRD1 protein in murine and human F508del-CFTR airway epithelial cell models. PMID: 21723850
- IFRD1 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
- This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in rat as nerve growth factor-inducible immediate early gene (named PC4). PMID: 2467301
- IFRD1 is an inducer of skeletal muscle regeneration and of satellite cell amplification, by regulating MyoD and NF-kB. PMID: 21127072
- Identification of PC4/IFRD1 as a coactivator of MyoD, a key master gene of muscle development. PMID: 15743821
- In the absence of PC4/IFRD1 skeletal muscle differentiation is defective. PMID: 7756174
- IFRD1 mRNA decay stress-sensitive regulation is mediated by an upstream open reading frame PMID: 20080976
- TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes PMID: 16204248
- identification of IFRD1 as a modifier of cystic fibrosis lung disease severity PMID: 19242412
- Sequence conservation, animal models, and protein structure evaluation support the involvement of IFRD1 in SMNA PMID: 19409521
- This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in mouse as TPA-inducible immediate early gene (named Tis7). PMID: 2797820
- Identification of the IFRD gene family, comprising the two genes PC4 / Tis7 / IFRD1 and SKMc15 / IFRD2, and in situ-hybridization analysis of their expression during developments PMID: 9722946
- PC4/IFRD1 is able to potentiate the transcription of many genes and to inhibit the transcription of few others, thus acting as regulator of transcription, possibly involved in tissue regeneration PMID: 12691737
- Functional ablation of PC4/IFRD1 in myoblast cells by sense and antisense strategies as well as by microinjection of PC4/IFRD1 antibodies, inhibits differentiation. PMID: 7756174
- PC4/IFRD1, known to be required for muscle differentiation, coactivates MyoD by relieving the HDAC4-mediated inhibition of MEF2C, as a result of its ability to dose-dependently displace HDAC4 from MEF2C. PMID: 15743821
- This reference (Tirone and Shooter 1989) shows the cloning and the sequence of the original IFRD1 homolog, isolated in rat as NGF-inducible immediate early gene (named PC4). PMID: 2467301
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蛋白家族：IFRD family
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組織特異性：Expressed in a variety of tissues.
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數據庫鏈接：
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