EXOSC8 Antibody
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中文名稱：EXOSC8兔多克隆抗體
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貨號：CSB-PA007896GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：bA421P11.3 antibody; CBP interacting protein 3 antibody; CIP3 antibody; EAP2 antibody; EC 3.1.13 antibody; EXOS8_HUMAN antibody; EXOSC8 antibody; Exosome complex component RRP43 antibody; Exosome complex exonuclease RRP43 antibody; Exosome component 8 antibody; OIP-2 antibody; OIP2 antibody; Opa interacting protein 2 antibody; Opa-interacting protein 2 antibody; OTTHUMP00000042274 antibody; p9 antibody; Ribosomal RNA processing protein 43 antibody; Ribosomal RNA processing protein 43; S. cerevisiae; homolog of antibody; Ribosomal RNA-processing protein 43 antibody; RP11 421P11.3 antibody; RRP43 antibody; Rrp43p antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human EXOSC8
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.
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基因功能參考文獻：
- homozygous missense mutations cause progressive and lethal neurological disease PMID: 24989451
- Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. PMID: 12419256
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相關疾病：Pontocerebellar hypoplasia 1C (PCH1C)
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亞細胞定位：Cytoplasm. Nucleus. Nucleus, nucleolus.
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蛋白家族：RNase PH family
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數據庫鏈接：
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