AMPD2 Antibody
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中文名稱：AMPD2兔多克隆抗體
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貨號(hào)：CSB-PA000869
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of COLO205 cells using AMPD2 Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：AMPD2
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別名：Adenosine monophosphate deaminase 2 (isoform L) antibody; Adenosine monophosphate deaminase 2 antibody; adenosine monophosphate deaminase 2 isoform L antibody; AMP deaminase 2 antibody; AMP deaminase isoform L antibody; AMPD 2 antibody; AMPD antibody; AMPD2 antibody; AMPD2_HUMAN antibody; RP5-1160K1.5 antibody; SPG63 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human AMPD2.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:5000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.
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基因功能參考文獻(xiàn)：
- Here we report the clinical and genetic analysis of an individual with PCH9 secondary to a novel missense variant with strong evidence of pathogenicity, located outside the catalytic domain of AMPD2 PMID: 28168832
- tofacitinib increases the cellular levels of adenosine, which is known to have anti-inflammatory activity, through the downregulation of AMPD2. This would be a novel functional aspect of tofacitinib. PMID: 25496463
- In human HepG2 cells, AMPD2 activation counterregulates AMPK and increases intracellular glucose production, in association with up-regulation of PEPCK and G6Pc. PMID: 24755741
- Study concluded that AMPD2 as necessary for guanine nucleotide biosynthesis and protein translation and provide evidence that AMP deaminase activity is critical during neurogenesis. Patients with mutations in AMPD2 have characteristic brain imaging features of pontocerebellar hypoplasia due to loss of brainstem and cerebellar parenchyma. PMID: 23911318
- N-terminal extensions of the AMPD2 polypeptide influence ATP regulation of isoform L. PMID: 12745092
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相關(guān)疾病：Pontocerebellar hypoplasia 9 (PCH9); Spastic paraplegia 63, autosomal recessive (SPG63)
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蛋白家族：Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family
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組織特異性：Highly expressed in cerebellum.
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數(shù)據(jù)庫(kù)鏈接：
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