Rat transforming growth factor α,TGF-α ELISA Kit

中文名稱：

大鼠轉化生長因子α(TGF-α)酶聯免疫試劑盒
貨號：

CSB-E07289r
規格：

96T/48T
價格：

￥3900/￥2500
促銷：
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

大鼠轉化生長因子α(TGF-α)酶聯免疫試劑盒（CSB-E07289r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的TGFA含量。TGFA即轉化生長因子α，是表皮生長因子家族成員。它可與表皮生長因子受體結合，激活下游信號通路，參與細胞的增殖、分化、遷移等過程。其異常表達與腫瘤等疾病的發生發展密切相關，是藥物研發的潛在靶點。試劑盒檢測范圍為7.8 pg/ml-500pg/ml，特別適用于動物模型中的創傷修復機制探究、腫瘤微環境研究或藥理學實驗中生物標志物動態監測。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

Tgfa ELISA Kit; Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha ELISA Kit; TGF-alpha ELISA Kit; EGF-like TGF ELISA Kit; ETGF ELISA Kit; TGF type 1)] ELISA Kit
縮寫：

TGFA
Uniprot No.：

P01134
種屬：

Rattus norvegicus (Rat)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

7.8 pg/ml-500pg/ml
靈敏度：

1.95 pg/ml
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Signal Transduction
測定原理：

quantitative
測定方法：

Sandwich
線性度：
數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

產品評價

靶點詳情

功能：

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
基因功能參考文獻：
1. 5-HT stimulates DNA synthesis and proliferation in primary cultures of adult rat hepatocytes by acting via autocrine secretion of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+ pathway. PMID: 26804134
2. Lipopolysaccharide exposure led to a suppression of both HDAC1 and HDAC2 expression and activity, induced TGFa expression, and disrupted alveolar morphology. PMID: 24595367
3. results support the hypothesis that FSH stimulates granulosa cell proliferation via theca TGFalpha secretion PMID: 12021046
4. A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei. PMID: 12029622
5. TGF-alpha exerts a neuroprotective action against NMDA toxicity, in which Erk1/2 activation plays a key role PMID: 12771152
6. TGF-alpha, laminin, and fibronectin are required for ovary follicle development and maturation PMID: 14656002
7. TGFalpha plays an autocrine role in LH dependent development and function of Leydig cells. PMID: 15353178
8. study adds TGFalpha to the list of dysregulated cytokines present in degrading cartilage in osteoarthritis PMID: 17968906
9. mechanical stretch promotes fetal type II cell differentiation via ectodomain shedding of HB-EGF and TGF-alpha PMID: 19237431
10. TGF-alpha has the ability to suppress anoikis of intestinal epithelial cells, at least in part, by reverting the loss of c-Src activity and Bcl-X(L) expression induced by detachment from the ECM. PMID: 11487584
顯示更多

收起更多
亞細胞定位：

[Transforming growth factor alpha]: Secreted, extracellular space.; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.
數據庫鏈接：

KEGG: rno:24827

STRING: 10116.ENSRNOP00000054248

UniGene: Rn.9952

Most popular with customers

Human Transforming Growth factor β1,TGF-β1 ELISA kit

Detect Range: 23.5 pg/ml-1500 pg/ml

Sensitivity: 5.8 pg/ml
Mouse Interleukin 1β,IL-1β ELISA Kit

Detect Range: 12.5 pg/ml-800 pg/ml

Sensitivity: 3.125 pg/ml
Human Interleukin 1β,IL-1β ELISA Kit

Detect Range: 2.344 pg/ml-150 pg/ml

Sensitivity: 0.586 pg/ml
Mouse Tumor necrosis factor α,TNF-α ELISA Kit

Detect Range: 7.8 pg/ml-500 pg/ml

Sensitivity: 1.95 pg/ml
Mouse Interleukin 6,IL-6 ELISA Kit

Detect Range: 3.9 pg/ml-250 pg/ml

Sensitivity: 0.975 pg/ml
Mouse Interleukin 2,IL-2 ELISA kit

Detect Range: 3.9 pg/ml-250 pg/ml

Sensitivity: 0.975 pg/ml
Mouse Interleukin 17,IL-17 ELISA Kit

Detect Range: 10.938 pg/ml-700 pg/ml

Sensitivity: 2.735 pg/ml
Human Interleukin 12,IL-12/P70 ELISA Kit

Detect Range: 3.9 pg/ml-250 pg/ml

Sensitivity: 0.975 pg/ml